PAPER Negi S, Khurana N, Duggal N
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PAPER Yang R, Li DD, Li XX, Yang XX, Gao HM, Zhang F
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
Int J Biol Macromol. 2024 May 7;269(Pt 2):132179. PubMed: 38723817Gael Nicolas on Do Two APOE4 Alleles Always Mean Alzheimer's?
COMMENT This is a very appealing study on neuropathological changes and in vivo biomarkers in APOE4 homozygotes. A better knowledge on the history of biomarkers in different genetic contexts is indeed required for the future of AD prevention, beyond autosomal dom
Beyond Microglia—Alzheimer’s Gene PLCγ2 Acts on Synapses, Too
RESEARCH NEWS 2024-05-09 Research News The Alzheimer’s risk gene phospholipase C-γ2 has been thought to act mainly in microglia. Now, in a May 1 preprint on bioRxiv, researchers led by Jean-Charles Lambert, Julie Dumont, and Julien Chapuis at Institut Pasteur de Lille, France, Mi
Arne Ittner on Beyond Microglia—Alzheimer’s Gene PLCγ2 Acts on Synapses, Too
COMMENT This study by Coulon et al. is a tour de force, identifying and characterising an exciting neuronal function for the AD gene PLCγ2, which encodes a phospholipase enzyme involved in signal transduction. The multilaboratory team established a loss-of-functi
PAPER Xu X, Wen X, Bhimani S, Moosa A, Parsons D, Ha H, Jin T
G protein-coupled receptor-mediated membrane targeting of PLCγ2 is essential for neutrophil chemotaxis.
J Leukoc Biol. 2023 Jul 27;114(2):126-141. PubMed: 37040618PAPER Xia Z, Storm DR
The role of calmodulin as a signal integrator for synaptic plasticity.
Nat Rev Neurosci. 2005 Apr;6(4):267-76. PubMed: 15803158PAPER Coulon A, Rabiller F, Takalo M, Roy A, Martiskainen H, Siedlecki-Wullich D, Mendes T, Lemeu C, Carvalho L-I, Ehrardt A, MelodeFerias AR, Hulsman M, Najdek C, Lannette-Weimann N, Freire-Regatillo A, Amouyel P, Charbonnier C, Dols-Icardo O, Jeskanen H, Kuulasmaa T, Kurki M, Hardy J, Wagner M, Heikkinen S, Holstege H, Makinen P, Nicolas G, Mead S, Wagner M, Ramirez A, Rauramaa T, Palotie A, Sims R, Soininen H, vanSwieten J, Williams J, Willman R-M, Bellenguez C, Grenier-Boley B, Gelle C, Lambert E, Ayral A-
Neuronal downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease hallmarks
bioRxiv2024.04.29.591575Csaba Adori on More Evidence that Locus Coeruleus Demise Precedes Cortical Tangles
COMMENT It is well known that certain subcortical modulatory nuclei, including the pigmented pontine nucleus locus coeruleus (LC), exhibit very early tau cytoskeletal pathology. According to earlier large-scale and detailed neuropathological studies by Heiko Braa
PhotoBioModulation
THERAPEUTICS Low level light therapy Low level laser therapy Cold laser therapy Transcranial infrared brain stimulation Transcranial photobiomodulation Transcranial near-infrared laser therapy (NILT) Transcranial low-level light therapy Procedural Intervention Inflamm
Alexa Pichet Binette on More Evidence that Locus Coeruleus Demise Precedes Cortical Tangles
COMMENT It is exciting to see the first paper investigating longitudinal locus coeruleus (LC) integrity and longitudinal tau-PET in vivo! Bueichekú and colleagues expanded on their previous pioneering studies. In a cohort of almost all cognitively unimpaired olde
Elliott Mufson on More Evidence that Locus Coeruleus Demise Precedes Cortical Tangles
COMMENT The is another in a series of articles discussing the integrity of locus coeruleus norepinephrine projection neurons and cortical tau pathology and cognition in Alzheimer’s disease. The authors examined whether LC changes precede tau deposition in the med
More Evidence that Locus Coeruleus Demise Precedes Cortical Tangles
RESEARCH NEWS 2024-05-09 Research News Cross-sectional autopsy studies have suggested that, in Alzheimer’s disease, neurofibrillary tangles first appear in the locus coeruleus (LC) of the brainstem. Now, a longitudinal imaging study lends support to that theory. In the April 25 N
Bill Howe
Clayton, United States